Animal models of major depression and their clinical implications
Czéh B. Fuchs E. Wiborg O. Simon M (2016). Animal models of major depression and their clinical implications. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 64, 293-310. https://doi.org/10.1016/j.pnpbp.2015.04.004
- Overall rating
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(5.0) 1 review
- Authors
- Boldizsár Czéh, Eberhard Fuchs, Ove Wiborg, Mária Simon
- Journal
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- First published
- 2016
- Number of citations
- 322
- Type
- Journal Article
- DOI
- 10.1016/j.pnpbp.2015.04.004
Reviews
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Discussion
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Not Open Access
HarlequinDenaturant
Apr 13, 2026
Although now relatively old, I found this paper extremely informative. I thought this was a well written, compelling, and nuanced exploration of the current scope of depression research in neuroscience and psychology and how animal models (particularly stress models of depression) can be both functionally inadequate or lacking while also proving to be fundamental to exploring the underlying neurobiology of depression. Results are critically analysed and limitations and criticisms are well-outlined and evocative. Really good!