Mechanisms of Nicotine Addiction

I would argue this is a paper more about nAChRs and their effects on behaviour, using nicotine as a model of stimulation rather than a paper about nicotine addiction. It was overall very informative but towards the end some discussion points felt like a reach (for example, "One possibility is that whereas optimal levels of ACh contribute to encoding of both rewarding and aversive stimuli, suprathreshold increases in ACh signaling, mediated by chronic stress or other stimuli that can lead to depression, favor encoding of aversive stimuli and lead to the type of negative encoding bias observed in human subjects with anxiety and depressive disorders" – this doesn't make theoretical sense to me?). Could do with more discussion of limitations of criticisms of studies mentioned.

0

0