Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism

Qin H. Yu J. Yu H. Zhou C. Yuan D. Wang Z. Zhu Z. Wei G. Ou P. Li Z. Jiang H. Shen J. Xiao G. Bai X. Wang H. Zhang H. Speakman J. Chen D. Tong L (2026). Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism. Cell Metabolism, 38(3), 582-597.e6. https://doi.org/10.1016/j.cmet.2026.01.008

Authors
Hongyu Qin, Jiamin Yu, Huan Yu, Chuqiao Zhou, Dongfeng Yuan, Ziling Wang, Zhenglin Zhu, Guizheng Wei, Peiyan Ou, Zhibin Li, Hua Jiang, Jie Shen, Guozhi Xiao, Xiaochun Bai, Huaiyu Wang, Huan-Tian Zhang, John R. Speakman, Di Chen, Liping Tong
Journal
Cell Metabolism
First published
2026
Type
Journal Article
DOI
10.1016/j.cmet.2026.01.008

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