Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex
He L. Wang X. Zhang J. Xiao Z. Hu X. Schwartenbeck P. Bakermans J. Behrens T. Liu Y (2026). Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex. Nature Neuroscience, 29(7), 1711-1721. https://doi.org/10.1038/s41593-026-02291-3
- Overall rating
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(4.0) 1 review
- Authors
- Li He, Xiongfei Wang, Jinbo Zhang, Zhibing Xiao, Xiangyu Hu, Philipp Schwartenbeck, Jacob Bakermans, Tim Behrens, Yunzhe Liu
- Journal
- Nature Neuroscience
- First published
- 2026
- Number of citations
- 1
- Type
- Journal Article
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Not Open Access
OliveMembrane
Jul 15, 2026
The paper presents valuable data on ripples and replay of neural sequences in humans during compositional reasoning. However, most of the statistics used mixed-effects models without random slopes leading to overestimation of effects and their statistical significance (i.e., some of the p-values are suspiciously small for a sample of 28 participants). Moreover, the core temporal delay modelling to assess sequenceness was only done in 5 participants because decoding didn't work for the other subjects. This undermines the strength of the central claim.