CHCHD4 is differentially expressed in central nervous system metastasis in human breast cancer.
Mamoor S (2023). CHCHD4 is differentially expressed in central nervous system metastasis in human breast cancer.., https://doi.org/10.31219/osf.io/8fmj3
- Authors
- Shahan Mamoor
- First published
- 2023
- Type
- Preprint
- DOI
- 10.31219/osf.io/8fmj3
Abstract
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that coiled-coil-helix-coiled-coil-helix domain-containing 4, encoded by CHCHD4, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CHCHD4 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CHCHD4 in primary tumors, however, was not correlated with patient distant metastasis-free survival. Modulation of CHCHD4 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
